![]() ![]() ![]() Changes in the microenvironment including alterations in mechanical forces, oxygen levels, chemokines, extracellular matrix and growth factor synthesis directly impact cellular recruitment and activation, leading to impaired states of wound healing. Unraveling the roles of each of these cell types and their interactions with each other is important in understanding the mechanisms of normal wound closure. There have also been discoveries of rare, stem cell subsets within the skin, which are unipotent in the uninjured state, but become multipotent following skin injury. ![]() With the evolution of single cell technologies, it has been possible to uncover phenotypic and functional heterogeneity within several of these cell types. It involves the spatial and temporal synchronization of a variety of cell types with distinct roles in the phases of hemostasis, inflammation, growth, re-epithelialization, and remodeling. Wound healing is one of the most complex processes in the human body. ![]()
0 Comments
Leave a Reply. |